The characteristics of the extreme drought event occurred from 1941 to 1943 in North China and its influence were analyzed in this paper. Results show that this drought event was the second extremely arid events during the Republic of China period,and He’ nan Province was the center of this event. It occurred on interdecadal relatively warm period and persisted long time. This drought event influenced so many provinces,and disaster was so serious with locust occurrence. It made population suffer severe losses and food prices soaring as well as ecological environment deterioration.